Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584385 | 0.91 | ADRB1 (0.56) | ADRB1ALDH1A1LMNACYP3A4HTR1A | |
| SCHEMBL6584380 | 0.91 | ADRB1 (0.56) | ADRB1ALDH1A1LMNACYP3A4HTR1A | |
| SCHEMBL8124793 | 0.84 | ADRA1D (0.59) | ADRB1ALDH1A1LMNACYP3A4HTR1A | |
| Ammonia Solution, Strong SCHEMBL9034232 | 0.83 | ADRB1 (0.61) | ADRB1ALDH1A1LMNACYP3A4HTR1A | |
| SCHEMBL8117978 | 0.81 | ADRB1 (0.56) | ADRB1ALDH1A1LMNACYP3A4HTR1A | |
| SCHEMBL31052020 | 0.81 | ADRB1 (0.67) | ADRB1ALDH1A1LMNACYP3A4HTR1A | |
| SCHEMBL6584182 | 0.81 | ADRB1 (0.58) | ADRB1ALDH1A1LMNACYP3A4HTR1A | |
| SCHEMBL13239004 | 0.80 | ADRB1 (0.71) | ADRB1ALDH1A1LMNACYP3A4HTR1A | |
| SCHEMBL6583554 | 0.80 | ADRA1D (0.52) | ADRB1ALDH1A1LMNACYP3A4HTR1A | |
| SCHEMBL6583818 | 0.79 | ADRB1 (0.56) | ADRB1ALDH1A1LMNACYP3A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867436-B1 | N-aryl-piperidine derivatives and their use as 5-HT1B receptor ligands | SERVIER LAB (FR) | 2004-06-09 | — | — | EP | disclosed |
| EP-0861837-B1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-04-28 | — | — | EP | disclosed |
| US-5968954-A | EXHIBIT SELECTIVE BINDING AFFINITY FOR 5-HYDROXYTRYPTAMINE RECEPTORS | ADIR ET COMPAGNIE (FR) | 1999-10-19 | — | — | US | disclosed |
| US-5965575-A | N-aryl piperidine compounds as 5HT1B antagonists | ADIR ET COMPAGNIE (FR) | 1999-10-12 | — | — | US | disclosed |
| EP-0867436-A1 | N-aryl-piperidine derivatives and their use as 5-HT1B receptor ligands | ADIR ET COMPAGNIE (FR) | 1998-09-30 | — | — | EP | disclosed |
| EP-0861837-A1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-09-02 | — | — | EP | disclosed |