Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.46 |
| ▸ | CHRNG | P07510 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583004 | 1.00 | KDM4E (0.48) | KDM4EBLMALOX15ALDH1A1CHRNA7 | |
| SCHEMBL6818552 | 0.82 | GRM5 (0.47) | KDM4EBLMALOX15 | |
| SCHEMBL6582956 | 0.80 | ALDH1A1 (0.46) | ALDH1A1CHRNA7CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6582951 | 0.80 | ALDH1A1 (0.46) | ALDH1A1CHRNA7CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6814104 | 0.80 | KDM4E (0.42) | KDM4EBLMALOX15 | |
| SCHEMBL6815035 | 0.79 | KDM4E (0.41) | KDM4EBLMALOX15 | |
| SCHEMBL6815030 | 0.79 | KDM4E (0.41) | KDM4EBLMALOX15 | |
| SCHEMBL6583042 | 0.79 | CHRNB4 (0.55) | ALDH1A1CHRNA7CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6583046 | 0.79 | CHRNB4 (0.55) | ALDH1A1CHRNA7CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6818619 | 0.78 | GRM5 (0.44) | BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1079860-B1 | NICOTINE IMMUNOGEN | INDEPENDENT PHARMACEUTICA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| EP-1265888-B1 | METHOD OF PRODUCING 6-SUBSTITUTED ( S )-NICOTINE DERIVATIVES AND INTERMEDIATE COMPOUNDS | INDEPENDENT PHARMACEUTICA AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| US-6656469-B1 | Treatment of nicotine dependence from tobacco products | INDEPENDENT PHARMACEUTICA AB (SE) | 2003-12-02 | — | — | US | disclosed |
| EP-1265888-A1 | METHOD OF PRODUCING 6-SUBSTITUTED ( i S /i )-NICOTINE DERIVATIVES AND INTERMEDIATE COMPOUNDS | Independent pharmaceutica AB (SE) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001070730-A1 | METHOD OF PRODUCING 6-SUBSTITUTED (S)-NICOTINE DERIVATIVES AND INTERMEDIATE COMPOUNDS | INDEPENDENT PHARMACEUTICA AB (SE) | 2001-09-27 | — | — | WO | disclosed |
| EP-1079860-A1 | NICOTINE IMMUNOGEN | Independent pharmaceutica AB (SE) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061054-A1 | NICOTINE IMMUNOGEN | INDEPENDENT PHARMACEUTICA AB (SE) | 1999-12-02 | — | — | WO | disclosed |