Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.47 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | PRKACA | P17612 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586657 | 0.80 | GSK3B (0.46) | GSK3BCDK5DYRK1ACLK4DYRK3 | |
| SCHEMBL27742050 | 0.79 | DYRK3 (0.51) | GSK3BCDK5DYRK1ACLK4DYRK3 | |
| SCHEMBL1363970 | 0.76 | DYRK3 (0.54) | GSK3BCDK5DYRK1ACLK4DYRK3 | |
| SCHEMBL6585051 | 0.72 | ROCK2 (0.58) | GSK3BCDK5DYRK1ACLK4DYRK3 | |
| SCHEMBL14196189 | 0.72 | GSK3B (0.57) | GSK3BCDK5DYRK1ACLK4DYRK3 | |
| SCHEMBL55886 | 0.72 | SLC6A2 (0.48) | CYP3A4 | |
| SCHEMBL2305985 | 0.71 | SLC6A4 (0.64) | GSK3BCDK5DYRK1ACLK4DYRK3 | |
| SCHEMBL3578324 | 0.70 | NR3C1 (0.51) | GSK3BCDK5DYRK1ACLK4DYRK3 | |
| SCHEMBL3587902 | 0.70 | NR3C1 (0.51) | GSK3BCDK5DYRK1ACLK4DYRK3 | |
| SCHEMBL3587907 | 0.70 | NR3C1 (0.51) | GSK3BCDK5DYRK1ACLK4DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390354-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | Amgen Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002083653-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |