Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLR1A | O95602 | 1/20 | 0.33 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582047 | 0.87 | POLB (0.37) | POLBGAANPSR1ALDH1A1 | |
| SCHEMBL6580384 | 0.87 | POLB (0.37) | POLBGAANPSR1ALDH1A1 | |
| SCHEMBL6948647 | 0.84 | GAA (0.42) | POLBGAANPSR1ALDH1A1POLR1A | |
| SCHEMBL6582239 | 0.75 | GAA (0.32) | GAA | |
| SCHEMBL6582588 | 0.75 | ELANE (0.30) | — | |
| SCHEMBL5734926 | 0.73 | POLB (0.40) | POLBGAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12440136 | 0.71 | GAA (0.40) | POLBGAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6950988 | 0.71 | GAA (0.40) | POLBGAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL988602 | 0.70 | ALDH1A1 (0.38) | GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL9300884 | 0.69 | POLB (0.47) | POLBGAANPSR1ALDH1A1POLR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155012-B1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER REC TECH LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6699861-B1 | ANTI-CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2004-03-02 | — | — | US | disclosed |
| EP-1155012-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | Cancer Research Ventures Limited (GB) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050417-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER RESEARCH VENTURES LIMITED (GB) | 2000-08-31 | — | — | WO | disclosed |