Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580601 | 0.87 | ALDH1A1 (0.46) | ALDH1A1KDM4ETDP1MAPK1TSHR | |
| SCHEMBL988163 | 0.85 | MAPT (0.38) | ALDH1A1KDM4EGLATDP1MAPK1 | |
| SCHEMBL988751 | 0.85 | MAPT (0.38) | ALDH1A1KDM4EGLATDP1MAPK1 | |
| SCHEMBL989078 | 0.77 | GRIN2D (0.40) | ALDH1A1KDM4ETDP1MAPK1TSHR | |
| SCHEMBL988873 | 0.74 | KDM4E (0.51) | ALDH1A1KDM4ETDP1MAPK1TSHR | |
| SCHEMBL987844 | 0.74 | PARP1 (0.39) | ALDH1A1KDM4EGLATSHRMAPT | |
| SCHEMBL987842 | 0.74 | PARP1 (0.39) | ALDH1A1KDM4EGLATSHRMAPT | |
| SCHEMBL6948647 | 0.74 | GAA (0.42) | ALDH1A1KDM4EGLATSHRTP53 | |
| SCHEMBL988879 | 0.72 | MAPT (0.37) | ALDH1A1KDM4EGLAMAPK1MAPT | |
| SCHEMBL6583200 | 0.70 | POLB (0.39) | ALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655398-B1 | EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT | BTG INT LTD (GB) | 2016-08-24 | — | — | EP | disclosed |
| EP-2213664-B1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES | BTG INT LTD (GB) | 2014-04-30 | — | — | EP | disclosed |
| EP-2213664-B1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES | BTG INT LTD (GB) | 2014-04-30 | — | — | EP | disclosed |
| US-8552016-B2 | Anti-cancer cyclopenta(g)quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2013-10-08 | — | — | US | disclosed |
| US-8486955-B2 | Anti-cancer cyclopenta [g] quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2013-07-16 | — | — | US | disclosed |
| US-8063056-B2 | Anti-cancer cyclopenta [g]quinazonline compounds | BTG INTERNATIONAL LIMITED (GB) | 2011-11-22 | — | — | US | disclosed |
| EP-1420809-B1 | USE OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES FOR TREATING CANCER | BTG INT LTD (GB) | 2011-09-28 | — | — | EP | disclosed |
| EP-1421069-B1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES | BTG INT LTD (GB) | 2011-08-10 | — | — | EP | disclosed |
| EP-1421069-B1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES | BTG INT LTD (GB) | 2011-08-10 | — | — | EP | disclosed |
| EP-2332962-A1 | Cyclopenta[g]quinazoline compounds for use in the treatment of inflammatory or allergic conditions | BTG International Limited (GB) | 2011-06-15 | — | — | EP | disclosed |
| US-7250511-B2 | Process for the preparation of cyclopenta[g]quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 2007-07-31 | — | — | US | disclosed |
| US-7250511-B2 | Process for the preparation of cyclopenta[g]quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 2007-07-31 | — | — | US | disclosed |
| US-7250511-B2 | Process for the preparation of cyclopenta[g]quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 2007-07-31 | — | — | US | disclosed |
| US-20050009851-A1 | Use of cyclopeta[g]quinazoline derivatives for treating cancer | BTG INTERNATIONAL LIMITED (GB) | 2005-01-13 | — | — | US | disclosed |
| US-20040266798-A1 | Process for the preparation of cyclopenta[g]quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 2004-12-30 | — | — | US | disclosed |
| US-20040242606-A1 | Anti-cancer cyclopenta (g)quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2004-12-02 | — | — | US | disclosed |
| EP-1420809-A1 | USE OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES FOR TREATING CANCER | BTG International Limited (GB) | 2004-05-26 | — | — | EP | disclosed |
| EP-1421069-A1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES | BTG International Limited (GB) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003020706-A1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[g]QUINAZOLINE DERIVATIVES | BTG INTERNATIONAL LIMITED (GB) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003020300-A1 | USE OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES FOR TREATING CANCER | BTG INTERNATIONAL LIMITED (GB) | 2003-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266798-A1 | Process for the preparation of cyclopenta[g]quinazoline derivatives | COX6A1, MT-ND6, CYP2D6 | ALDH1A1 1243/4885KDM4E 2594/4885GLA 2598/4885 |
| US-20040242606-A1 | Anti-cancer cyclopenta (g)quinazoline compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR1, NR4A1 | ALDH1A1 808/4885KDM4E 1184/4885GLA 1324/4885 |
| US-20050009851-A1 | Use of cyclopeta[g]quinazoline derivatives for treating cancer | CNR1, NR3C1, NR0B1 | ALDH1A1 850/4885KDM4E 4184/4885GLA 3893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.