SCHEMBL6583296

SCHEMBL6583296

COCCOc1cncc(O)c1

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.49
CHRNA4 P43681 3/20 0.49
CHRNB4 P30926 2/20 0.49
CHRNA3 P32297 2/20 0.49
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
GGPS1 O95749 2/20 0.38
CYP3A4 P08684 1/20 0.37
ADORA2A P29274 1/20 0.37
ADORA1 P30542 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13541415 0.81 LTA4H (0.50) CHRNB2CHRNA4CHRNB4CHRNA3GGPS1
SCHEMBL23461674 0.81 CHRNB2 (0.48) CHRNB2CHRNA4CYP11B1CYP11B2CYP3A4
SCHEMBL29996980 0.81 CHRNB2 (0.48) CHRNB2CHRNA4CYP11B1CYP11B2CYP3A4
SCHEMBL12017395 0.79 CHRNB2 (0.48) CHRNB2CHRNA4CHRNB4CHRNA3CYP3A4
SCHEMBL13097276 0.79 CHRNB4 (0.43) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL30472090 0.79 GGPS1 (0.45) CHRNB2CHRNA4CYP11B1CYP11B2GGPS1
SCHEMBL25627325 0.79 GGPS1 (0.45) CHRNB2CHRNA4CYP11B1CYP11B2GGPS1
SCHEMBL31103456 0.79 CHRNB4 (0.49) CHRNB2CHRNA4CHRNB4CHRNA3CYP11B1
SCHEMBL4318683 0.79 CHRNB4 (0.49) CHRNB2CHRNA4CHRNB4CHRNA3CYP11B1
SCHEMBL31052372 0.78 CHRNB4 (0.41) CHRNB2CHRNA4CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP disclosed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed