SCHEMBL6583520

SCHEMBL6583520

CN1CC[C@H]1COc1cncc(C=Cc2ccncc2)c1

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 5/20 0.87
CHRNB1 P11230 3/20 0.87
CHRNB4 P30926 3/20 0.87
CHRNA3 P32297 3/20 0.87
CHRNB3 Q05901 3/20 0.87
AKT1 P31749 6/20 0.66
ROCK2 O75116 2/20 0.66
PIM1 P11309 2/20 0.66
PRKCD Q05655 2/20 0.66
ROCK1 Q13464 2/20 0.66
DYRK1A Q13627 2/20 0.66
PRKD2 Q9BZL6 2/20 0.66
DAPK3 O43293 1/20 0.66
PRKCG P05129 1/20 0.66
RPS6KB1 P23443 1/20 0.66
LIMK1 P53667 1/20 0.66
CDK5 Q00535 1/20 0.66
PAK1 Q13153 1/20 0.66
STK3 Q13188 1/20 0.66
CDC42BPA Q5VT25 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7674161 0.99 CHRNB2 (0.85) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL6583361 0.93 CHRNB2 (1.00) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL6583359 0.93 CHRNB2 (1.00) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
Hydrochloric Acid SCHEMBL6585314 0.92 CHRNB2 (0.98) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
Hydrochloric Acid SCHEMBL6585317 0.92 CHRNB2 (0.98) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL6588752 0.84 CHRNB2 (1.00) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL6583713 0.84 CHRNB2 (1.00) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL6583448 0.84 CHRNB2 (1.00) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
Trifluoroacetic Acid SCHEMBL6833540 0.83 CHRNB2 (0.77) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
Hydrochloric Acid SCHEMBL6584652 0.83 CHRNB2 (0.98) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP claimed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US claimed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed
US-5629325-A TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS ABBOTT LABORATORIES (US) 1997-05-13 US disclosed