Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.77 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.77 |
| ▸ | CHRNB3 | Q05901 | 6/20 | 0.77 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.77 |
| ▸ | CHRNB1 | P11230 | 5/20 | 0.77 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.59 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583359 | 0.87 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 | |
| SCHEMBL6583361 | 0.87 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 | |
| Hydrochloric Acid SCHEMBL6585314 | 0.86 | CHRNB2 (0.98) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 | |
| Hydrochloric Acid SCHEMBL6585317 | 0.86 | CHRNB2 (0.98) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 | |
| SCHEMBL6583520 | 0.83 | CHRNB2 (0.87) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 | |
| Hydrochloric Acid SCHEMBL7674161 | 0.82 | CHRNB2 (0.85) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 | |
| SCHEMBL6583448 | 0.81 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 | |
| SCHEMBL6583713 | 0.81 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 | |
| SCHEMBL6588752 | 0.81 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 | |
| Hydrochloric Acid SCHEMBL6584652 | 0.80 | CHRNB2 (0.98) | CHRNB2CHRNA3CHRNB3CHRNB4CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831175-B2 | Such as N,N-dimethyl-N-(2-((5-((E)-2-pyridin-4-ylvinyl) pyridin-3-yl)oxy)ethyl)amine | ABBOTT LABORATORIES | 2004-12-14 | — | — | US | claimed |
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | claimed |
| US-20030199511-A1 | Kinase inhibitors | ABBVIE INC. | 2003-10-23 | — | — | US | claimed |
| US-20030187026-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-10-02 | — | — | US | claimed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | claimed |
| US-6831175-B2 | Such as N,N-dimethyl-N-(2-((5-((E)-2-pyridin-4-ylvinyl) pyridin-3-yl)oxy)ethyl)amine | ABBOTT LABORATORIES | 2004-12-14 | — | — | US | disclosed |
| US-20030199511-A1 | Kinase inhibitors | ABBVIE INC. | 2003-10-23 | — | — | US | disclosed |
| US-20030187026-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187026-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | CHRNB2 4672/4885CHRNA3 4788/4885CHRNB3 4671/4885 |
| US-20030199511-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | CHRNB2 4672/4885CHRNA3 4788/4885CHRNB3 4671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.