Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.47 |
| ▸ | AR | P10275 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5414904 | 0.89 | AR (0.50) | APLNRARMEN1KMT2APDE2A | |
| SCHEMBL5407528 | 0.88 | AR (0.49) | APLNRARMEN1KMT2APDE2A | |
| SCHEMBL6583694 | 0.87 | LMNA (0.44) | ARCYP1A2PDE10A | |
| SCHEMBL6584411 | 0.85 | PDE10A (0.44) | ARMEN1KMT2ACYP1A2PDE10A | |
| SCHEMBL5420226 | 0.83 | KDM4E (0.46) | APLNRARMEN1KMT2A | |
| SCHEMBL6584270 | 0.82 | PDE2A (0.44) | CYP1A2PDE10APDE2A | |
| SCHEMBL5412668 | 0.81 | MEN1 (0.54) | APLNRARMEN1KMT2APDE2A | |
| SCHEMBL6618378 | 0.79 | CYP3A4 (0.44) | CYP1A2PDE10APDE2A | |
| SCHEMBL5410441 | 0.79 | MEN1 (0.47) | APLNRARMEN1KMT2APDE2A | |
| SCHEMBL7719001 | 0.78 | CYP1A2 (0.39) | MEN1KMT2ACYP1A2PDE10APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404656-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003006438-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-23 | — | — | WO | disclosed |