Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5418003 | 0.89 | AR (0.49) | SMN1; SMN2AR | |
| SCHEMBL6583523 | 0.87 | APLNR (0.47) | CYP1A2PDE10AAR | |
| SCHEMBL5409644 | 0.87 | MAPT (0.47) | LMNASMN1; SMN2L3MBTL1MAPTAR | |
| SCHEMBL6584411 | 0.86 | PDE10A (0.44) | CYP1A2PDE10AMAPTAR | |
| SCHEMBL5430129 | 0.82 | HPGD (0.45) | LMNASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5417222 | 0.82 | MEN1 (0.50) | LMNASMN1; SMN2 | |
| SCHEMBL5410432 | 0.80 | MAPT (0.50) | LMNAALDH1A1MAPTNPSR1 | |
| SCHEMBL5414904 | 0.79 | AR (0.50) | AR | |
| SCHEMBL6584270 | 0.78 | PDE2A (0.44) | CYP1A2PDE10ACYP3A4MAPTCYP2C9 | |
| SCHEMBL4921507 | 0.78 | NPC1 (0.46) | LMNASMN1; SMN2L3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404656-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003006438-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-23 | — | — | WO | disclosed |