SCHEMBL7560728

CCOC(=O)C(C)(C)Oc1ccc(CNC(=O)c2nc(-c3ccc(C(F)(F)F)cc3)sc2C)cc1.CCOC(=O)C(C)(C)Oc1ccc(CNC(=O)c2sc(-c3ccc(C(C)C)cc3)nc2C)cc1C.CCOC(=O)C(C)(C)Oc1ccc(CNC(=O)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C.Cc1cc(CNC(=O)c2sc(-c3ccc(C(C)C)cc3)nc2C)ccc1OC(C)(C)C(=O)O.Cc1cc(CNC(=O)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OC(C)(C)C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	PPARA	Q07869	20/20	0.64

▸	PPARD	Q03181	11/20	0.64

▸	PPARG	P37231	5/20	0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6583596	0.85	PPARA (0.64)	PPARAPPARDPPARG
SCHEMBL6584688	0.85	PPARA (0.53)	PPARAPPARDPPARG
SCHEMBL6580900	0.83	PPARA (0.77)	PPARAPPARDPPARG
SCHEMBL6582786	0.83	PPARA (0.64)	PPARAPPARDPPARG
SCHEMBL5185069	0.82	PPARA (0.82)	PPARAPPARDPPARG
SCHEMBL6582869	0.82	PPARA (0.67)	PPARAPPARDPPARG
SCHEMBL6582575	0.82	PPARA (0.63)	PPARAPPARDPPARG
SCHEMBL7470854	0.81	PPARA (0.68)	PPARAPPARDPPARG
SCHEMBL7467464	0.81	PPARA (0.68)	PPARAPPARDPPARG
SCHEMBL6582860	0.80	PPARA (0.77)	PPARAPPARDPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1244642-A1	SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS	GLAXO GROUP LIMITED (GB)	2002-10-02	—	—	EP	claimed
WO-2001040207-A1	SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS	GLAXO GROUP LIMITED (GB)	2001-06-07	—	—	WO	claimed