SCHEMBL6583669

SCHEMBL6583669

CC(C)(C)OC(=O)N1CC[C@H]1COc1cnc(Cl)c(C(=O)c2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.40
PKM P14618 1/20 0.40
ALOX5AP P20292 3/20 0.39
POLB P06746 1/20 0.39
ABCB1 P08183 1/20 0.39
FEN1 P39748 1/20 0.39
BTK Q06187 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
GPR119 Q8TDV5 2/20 0.37
HPGDS O60760 1/20 0.37
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA7 P36544 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6585104 0.93 CHRNB2 (0.38) BTKCHRNB4CHRNA3CHRNA7
SCHEMBL7133644 0.88 ALOX5AP (0.40) ALOX5APPOLBFEN1MEN1KMT2A
SCHEMBL7413516 0.85 PARP1 (0.41) ALOX5APPOLBFEN1GPR119CHRNB4
SCHEMBL6587429 0.85 KDM4E (0.45) KDM4EPKMALOX5AP
SCHEMBL6586830 0.85 CHRNB4 (0.50) ALOX5APCHRNB4CHRNA3CHRNA7
SCHEMBL6586921 0.85 CHRNB4 (0.50) ALOX5APCHRNB4CHRNA3CHRNA7
SCHEMBL7526443 0.84 KDM4E (0.49) KDM4EPKMALOX5APPOLBFEN1
SCHEMBL7525011 0.84 KDM4E (0.49) KDM4EPKMALOX5APPOLBFEN1
SCHEMBL7470605 0.83 ALOX5AP (0.41) ALOX5APFEN1MEN1KMT2AGPR119
SCHEMBL7478777 0.81 ALOX5AP (0.39) ALOX5APFEN1GPR119CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP disclosed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed
US-5629325-A TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS ABBOTT LABORATORIES (US) 1997-05-13 US disclosed