SCHEMBL6583673

SCHEMBL6583673

Nc1cccc(-c2cncc(OC[C@@H]3CCCN3)c2)c1

nearest known ligand 0.63

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 6/20 0.63
CHRNA4 P43681 5/20 0.63
CHRNB4 P30926 4/20 0.61
CHRNA3 P32297 4/20 0.61
CHRNB1 P11230 2/20 0.61
CHRNB3 Q05901 1/20 0.61
PRKCZ Q05513 1/20 0.59
CHRNA1 P02708 1/20 0.55
CHRNG P07510 1/20 0.55
CHRND Q07001 1/20 0.55
AKT1 P31749 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6582207 1.00 CHRNB2 (0.63) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
Hydrochloric Acid SCHEMBL6583823 0.99 CHRNB2 (0.62) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
Hydrochloric Acid SCHEMBL6585766 0.99 CHRNB2 (0.62) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
SCHEMBL6583461 0.92 CHRNB2 (0.75) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
Hydrochloric Acid SCHEMBL6585326 0.91 CHRNB2 (0.73) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
SCHEMBL6585946 0.87 CHRNB2 (0.83) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
SCHEMBL6584663 0.87 CHRNB2 (0.83) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
Hydrochloric Acid SCHEMBL6583887 0.86 CHRNB2 (0.81) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
Hydrochloric Acid SCHEMBL6588481 0.86 CHRNB2 (0.81) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
SCHEMBL3361597 0.83 CHRNB2 (0.58) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP claimed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US claimed
EP-0934308-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1999-08-11 EP claimed
WO-1997046554-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1997-12-11 WO claimed
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP disclosed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed
EP-0934308-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1999-08-11 EP disclosed
WO-1997046554-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1997-12-11 WO disclosed