SCHEMBL6585946

SCHEMBL6585946

c1ccc(-c2cncc(OC[C@@H]3CCCN3)c2)cc1

nearest known ligand 0.83

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 8/20 0.83
CHRNA4 P43681 8/20 0.83
CHRNB4 P30926 2/20 0.67
CHRNA3 P32297 2/20 0.67
CHRNA1 P02708 1/20 0.67
CHRNG P07510 1/20 0.67
CHRNB1 P11230 1/20 0.67
CHRND Q07001 1/20 0.67
LTA4H P09960 2/20 0.60
AKT1 P31749 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6584663 1.00 CHRNB2 (0.83) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
Hydrochloric Acid SCHEMBL6588481 0.99 CHRNB2 (0.81) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
Hydrochloric Acid SCHEMBL6583887 0.99 CHRNB2 (0.81) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL6587381 0.91 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA3
SCHEMBL14941047 0.91 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA3
Hydrochloric Acid SCHEMBL6585349 0.90 CHRNB2 (0.97) CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL6584096 0.90 CHRNB2 (0.97) CHRNB2CHRNA4
SCHEMBL6588519 0.88 CHRNB2 (0.64) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL6583246 0.88 CHRNB2 (0.64) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL6583673 0.87 CHRNB2 (0.63) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP claimed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US claimed
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP disclosed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed
EP-0934308-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1999-08-11 EP disclosed
WO-1997046554-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1997-12-11 WO disclosed
US-5629325-A TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS ABBOTT LABORATORIES (US) 1997-05-13 US disclosed