Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585192 | 0.88 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL6582369 | 0.83 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL6586329 | 0.80 | PDE4A (0.40) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL6584335 | 0.79 | PDE4B (0.44) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL6587626 | 0.79 | PDE4B (0.48) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL7320846 | 0.78 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6586360 | 0.77 | PDE4B (0.44) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL986885 | 0.75 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6508090 | 0.75 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6583489 | 0.73 | PDE4B (0.42) | PDE4APDE4DPDE4BPDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |