Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 11/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586360 | 0.89 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL6587626 | 0.82 | PDE4B (0.48) | PDE4BCASP1HSD17B10PDE4APDE4C | |
| SCHEMBL6231255 | 0.80 | CASP1 (0.55) | PDE4BCASP1HSD17B10PDE4APDE4C | |
| SCHEMBL6585192 | 0.78 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL14027108 | 0.78 | CASP1 (0.48) | PDE4BCASP1HSD17B10PDE4APDE4C | |
| SCHEMBL6815488 | 0.77 | CASP1 (0.54) | PDE4BCASP1HSD17B10PDE4APDE4C | |
| SCHEMBL6826307 | 0.74 | CASP1 (0.54) | PDE4BCASP1HSD17B10PDE4APDE4C | |
| SCHEMBL6582369 | 0.74 | PDE4A (0.46) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL6584335 | 0.74 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7355456 | 0.74 | PDE4A (0.51) | PDE4BPDE4APDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |