Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585856 | 0.88 | CASP1 (0.45) | — | |
| SCHEMBL6582369 | 0.82 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6584335 | 0.82 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6585192 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6583778 | 0.80 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6587626 | 0.78 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6586360 | 0.76 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6583489 | 0.73 | PDE4B (0.42) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7322059 | 0.71 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9269715 | 0.71 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |