Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18649060 | 0.98 | USP2 (0.53) | USP2LMNAHRH2CYP1A2CYP3A4 | |
| SCHEMBL25530345 | 0.98 | USP2 (0.53) | USP2LMNAHRH2CYP1A2CYP3A4 | |
| SCHEMBL26432247 | 0.98 | USP2 (0.53) | USP2LMNAHRH2CYP1A2CYP3A4 | |
| SCHEMBL4629926 | 0.94 | — | — | |
| SCHEMBL4222977 | 0.85 | — | — | |
| SCHEMBL24566374 | 0.78 | USP2 (0.42) | USP2LMNAHRH2CYP1A2CYP3A4 | |
| SCHEMBL4711257 | 0.77 | — | — | |
| SCHEMBL25421446 | 0.77 | — | — | |
| SCHEMBL12988348 | 0.76 | USP2 (0.52) | USP2LMNAHRH2CYP1A2CYP3A4 | |
| SCHEMBL241536 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116082343-A | Synthesis method of pyrazolo isoindole derivative | 嘉兴学院 | 2023-05-09 | — | — | CN | claimed |
| CN-105949200-A | Method for synthesizing 5-arylpyrazole [1, 5-alpha] pyrimindine derivatives | 重庆医药高等专科学校 | 2016-09-21 | — | — | CN | claimed |
| CN-116082343-A | Synthesis method of pyrazolo isoindole derivative | 嘉兴学院 | 2023-05-09 | — | — | CN | disclosed |
| CN-108484503-A | A kind of preparation method of aryl substituted pyrazolecarboxylic and its derivative | 常州大学 | 2018-09-04 | — | — | CN | disclosed |
| CN-108329264-A | A kind of 5- aryl -3- phenoxy groups -1- hydrogen-pyrazole compound and preparation method thereof | 福州大学 | 2018-07-27 | — | — | CN | disclosed |
| CN-106008520-A | Synthesis method of 5-arylpyrazolopyrimidine derivatives | 重庆医药高等专科学校 | 2016-10-12 | — | — | CN | disclosed |
| CN-105949200-A | Method for synthesizing 5-arylpyrazole [1, 5-alpha] pyrimindine derivatives | 重庆医药高等专科学校 | 2016-09-21 | — | — | CN | disclosed |
| CN-105949200-A | Method for synthesizing 5-arylpyrazole [1, 5-alpha] pyrimindine derivatives | 重庆医药高等专科学校 | 2016-09-21 | — | — | CN | disclosed |
| CN-105949200-A | Method for synthesizing 5-arylpyrazole [1, 5-alpha] pyrimindine derivatives | 重庆医药高等专科学校 | 2016-09-21 | — | — | CN | disclosed |
| US-20140315956-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | NATIONWIDE CHILDREN'S HOSPITAL (US) | 2014-10-23 | — | — | US | disclosed |
| WO-2013019690-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | THE OHIO STATE UNIVERSITY (US) | 2013-02-07 | — | — | WO | disclosed |
| US-5496956-A | BY ESTERIFICATION OF CARBOXY SUBSTITUTION WITH ALCOHOLS IN THE PRESENCE OF MINERAL ACID | MONSANTO COMPANY (US) | 1996-03-05 | — | — | US | disclosed |
| US-5489571-A | CROP-SAFE COMPOUNDS EFFECTIVE AT LOW CONCENTRATIONS | MONSANTO COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| CN-1030595-C | Substituted aryl-haloalkyl-pyrazoles as herbicides | MONSANTO CO (US) | 1996-01-03 | — | — | CN | disclosed |
| CN-1090845-A | Process for preparing substituted aryl-halogenoalkyl pyrazoles | MONSANTO CO (US) | 1994-08-17 | — | — | CN | disclosed |
| US-5281571-A | Herbicidal benzoxazinone- and benzothiazinone-substituted pyrazoles | MONSANTO COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0553307-A1 | HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES | MONSANTO COMPANY (US) | 1993-08-04 | — | — | EP | disclosed |
| CN-1061777-A | Substituted aryl-haloalkyl-pyrazoles as herbicides | MONSANTO CO (US) | 1992-06-10 | — | — | CN | disclosed |
| CN-1061221-A | The aryl alkylsulfonyl pyrazoles of the replacement of weeding | MONSANTO CO (US) | 1992-05-20 | — | — | CN | disclosed |
| WO-1992006962-A1 | HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES | MONSANTO COMPANY (US) | 1992-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315956-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | IL6, STAT3, JAK2 | USP2 3457/4885LMNA 4752/4885HRH2 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.