Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202033 | 0.80 | HTR6 (0.66) | HTR6CYP1A2HTR1AHTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL5201694 | 0.79 | HTR6 (0.65) | HTR6CYP1A2HTR1AHTR1BHTR2A | |
| SCHEMBL6585144 | 0.75 | HTR6 (0.60) | HTR6CYP1A2HTR1AHTR1BHTR2A | |
| SCHEMBL6589771 | 0.72 | HTR6 (0.61) | HTR6HTR3EHTR3BCYP1A2HTR1A | |
| SCHEMBL233169 | 0.72 | ADRB1 (0.58) | HTR6HTR3EHTR3BCYP1A2HTR1A | |
| SCHEMBL3621241 | 0.72 | HTR6 (0.50) | HTR6HTR2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL29882725 | 0.71 | ADRB1 (0.56) | HTR6HTR3EHTR3BCYP1A2HTR1A | |
| Hydrochloric Acid SCHEMBL20139829 | 0.71 | ADRB1 (0.56) | HTR6HTR3EHTR3BCYP1A2HTR1A | |
| SCHEMBL5483901 | 0.70 | HTR6 (0.74) | HTR6 | |
| SCHEMBL1136474 | 0.70 | HTR6 (0.76) | HTR6HTR3EHTR3BCYP1A2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414442-A1 | 3-ARYLSULFONYL-7-PIPERAZINYL- INDOLES, -BENZOFURANS AND -BENZOTHIOPHENES WITH 5-HT6 RECEPTOR AFFINITY FOR TREATING CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2004-05-06 | — | — | EP | claimed |
| WO-2003013510-A1 | 3-ARYLSULFONYL-7-PIPERAZINYL- INDOLES, -BENZOFURANS AND -BENZOTHIOPHENES WITH 5-HT6 RECEPTOR AFFINITY FOR TREATING CNS DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-02-20 | — | — | WO | claimed |