SCHEMBL6584479

SCHEMBL6584479

COc1cccc(-c2ccc(C3CCN(S(=O)(=O)C4(C(=O)NO)CCC4)CC3)cc2C)c1

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 13/20 0.56
MMP3 P08254 9/20 0.56
MMP9 P14780 5/20 0.55
MMP1 P03956 4/20 0.55
MMP14 P50281 3/20 0.55
MMP13 P45452 6/20 0.43
USP5 P45974 1/20 0.41
ADAM17 P78536 1/20 0.40
HCRTR1 O43613 3/20 0.39
HCRTR2 O43614 3/20 0.39
ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6586370 0.98 MMP2 (0.56) MMP2MMP3MMP9MMP1MMP14
SCHEMBL6586955 0.94 MMP2 (0.54) MMP2MMP3MMP9MMP1MMP14
SCHEMBL6585463 0.93 MMP2 (0.53) MMP2MMP3MMP9MMP1MMP14
SCHEMBL6433872 0.92 MMP2 (0.55) MMP2MMP3MMP9MMP1MMP14
SCHEMBL6433867 0.92 MMP2 (0.55) MMP2MMP3MMP9MMP1MMP14
SCHEMBL6433864 0.92 MMP2 (0.55) MMP2MMP3MMP9MMP1MMP14
SCHEMBL6587738 0.91 MMP2 (0.53) MMP2MMP3MMP9MMP1MMP14
SCHEMBL6583780 0.91 MMP2 (0.54) MMP2MMP3MMP9MMP1MMP14
SCHEMBL6586632 0.90 MMP2 (0.52) MMP2MMP3MMP9MMP1MMP14
SCHEMBL6965267 0.88 MMP2 (0.51) MMP2MMP3MMP9MMP1MMP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1036062-B1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS PFIZER LTD (GB) 2004-01-02 EP claimed
US-6495568-B1 TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES WARNER-LAMBERT COMPANY 2002-12-17 US claimed
EP-1036062-A1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS Pfizer Limited (GB) 2000-09-20 EP claimed
WO-1999029667-A1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS PFIZER LIMITED (GB) 1999-06-17 WO claimed
EP-1036062-B1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS PFIZER LTD (GB) 2004-01-02 EP disclosed
US-6495568-B1 TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES WARNER-LAMBERT COMPANY 2002-12-17 US disclosed
EP-1036062-A1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS Pfizer Limited (GB) 2000-09-20 EP disclosed
WO-1999029667-A1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS PFIZER LIMITED (GB) 1999-06-17 WO disclosed