Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585910 | 0.86 | HTR1A (0.47) | HTR1ADRD2HTR2A | |
| SCHEMBL6583374 | 0.86 | HTR1A (0.58) | HTR1ADRD2 | |
| SCHEMBL6584899 | 0.85 | HTR1A (0.46) | HTR1ADRD2HTR2ADRD4DRD3 | |
| SCHEMBL6582162 | 0.85 | HTR1A (0.57) | HTR1ADRD2HTR2A | |
| SCHEMBL6583915 | 0.82 | HTR1A (0.45) | HTR1ADRD2HTR2ADRD1 | |
| SCHEMBL6582184 | 0.80 | HTR1A (0.40) | HTR1ADRD2HTR2A | |
| SCHEMBL6582770 | 0.78 | HTR1A (0.49) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL6585033 | 0.76 | HTR1A (0.47) | HTR1ADRD2HTR2A | |
| SCHEMBL6581720 | 0.75 | HTR1A (0.49) | HTR1A | |
| SCHEMBL7481888 | 0.72 | HTR1A (0.59) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861837-B1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-04-28 | — | — | EP | claimed |
| EP-0861837-A1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-09-02 | — | — | EP | claimed |
| EP-0861837-B1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-04-28 | — | — | EP | disclosed |
| US-5968954-A | EXHIBIT SELECTIVE BINDING AFFINITY FOR 5-HYDROXYTRYPTAMINE RECEPTORS | ADIR ET COMPAGNIE (FR) | 1999-10-19 | — | — | US | disclosed |
| EP-0861837-A1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-09-02 | — | — | EP | disclosed |