Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 7/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | DRD1 | P21728 | 3/20 | 0.36 |
| ▸ | DRD5 | P21918 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585910 | 0.89 | HTR1A (0.47) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6582162 | 0.87 | HTR1A (0.57) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6583915 | 0.85 | HTR1A (0.45) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6585688 | 0.85 | HTR1A (0.50) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL6584486 | 0.85 | NPY1R (0.44) | HTR1ADRD2HTR2ADRD4DRD3 | |
| SCHEMBL6582184 | 0.83 | HTR1A (0.40) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6582770 | 0.81 | HTR1A (0.49) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6585033 | 0.78 | HTR1A (0.47) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7482608 | 0.76 | HTR1A (0.56) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7479086 | 0.76 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861837-B1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-04-28 | — | — | EP | claimed |
| CN-1090627-C | New 2-amino-1,2-indene compounds, process for their preparation and pharmaceutical compositions containing them | SEUER LAB (FR) | 2002-09-11 | — | — | CN | claimed |
| CN-1194983-A | New 2-amino-1,2-indene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-10-07 | — | — | CN | claimed |
| EP-0861837-A1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-09-02 | — | — | EP | claimed |
| EP-0861837-B1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-04-28 | — | — | EP | disclosed |
| US-5968954-A | EXHIBIT SELECTIVE BINDING AFFINITY FOR 5-HYDROXYTRYPTAMINE RECEPTORS | ADIR ET COMPAGNIE (FR) | 1999-10-19 | — | — | US | disclosed |
| EP-0861837-A1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-09-02 | — | — | EP | disclosed |