Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338294 | 0.80 | SMN1; SMN2 (0.34) | PREPCYP1A2CCR1 | |
| SCHEMBL6586747 | 0.75 | HRH1 (0.50) | HRH1PREPCYP1A2OPRK1ELANE | |
| SCHEMBL6581748 | 0.74 | BCHE (0.50) | HRH1BCHEACHE | |
| SCHEMBL6581751 | 0.73 | HRH1 (0.42) | HRH1PREPOPRK1ELANECCR1 | |
| SCHEMBL23137089 | 0.70 | ATM (0.49) | CYP1A2OPRK1ELANECYP3A4TSHR | |
| SCHEMBL4802049 | 0.67 | AAK1 (0.44) | HRH1OPRK1TSHRCTSK | |
| SCHEMBL19924794 | 0.67 | HRH1 (0.62) | HRH1OPRK1BCHEACHECTSK | |
| SCHEMBL19924796 | 0.67 | HRH1 (0.62) | HRH1OPRK1BCHEACHECTSK | |
| SCHEMBL23135998 | 0.67 | DPP4 (0.49) | PREPCYP1A2OPRK1ELANECCR1 | |
| SCHEMBL29802251 | 0.66 | CCR1 (0.47) | CYP1A2OPRK1CCR1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815080-B1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA (IT) | 2004-06-16 | — | — | EP | disclosed |
| US-6002009-A | Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity | BOEHRINGER INGELHEIM ITALIA, S.P.A. (IT) | 1999-12-14 | — | — | US | disclosed |
| EP-0815080-A1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT 4? ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028424-A1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-09-19 | — | — | WO | disclosed |