Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.61 |
| ▸ | CA9 | Q16790 | 3/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664384 | 0.89 | CA12 (0.59) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL28911652 | 0.87 | CA12 (0.70) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL9468420 | 0.82 | SCN2A (0.74) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL28911681 | 0.82 | CA12 (0.65) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL10381359 | 0.81 | SCN2A (0.82) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL10425042 | 0.80 | CA12 (0.61) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL6581433 | 0.80 | CA12 (0.61) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL4779948 | 0.79 | CA12 (0.68) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL406359 | 0.79 | CA12 (0.72) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL1468419 | 0.79 | CA12 (0.64) | CA12CA9CA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192131-B1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES | WARNER LAMBERT CO (US) | 2004-08-04 | — | — | EP | disclosed |
| EP-1192131-A1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076969-A1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |