Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.40 |
| ▸ | GABRD | O14764 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12987414 | 0.84 | LMNA (0.47) | LMNATHRBKMT2AALDH1A1TSHR | |
| SCHEMBL11264031 | 0.77 | LMNA (0.40) | LMNATHRBKMT2AALDH1A1TSHR | |
| SCHEMBL15621601 | 0.77 | LMNA (0.40) | LMNATHRBKMT2AALDH1A1TSHR | |
| SCHEMBL28320255 | 0.76 | ALDH1A1 (0.42) | LMNATHRBKMT2AALDH1A1TSHR | |
| SCHEMBL149291 | 0.75 | LMNA (0.38) | LMNATHRBKMT2AALDH1A1TSHR | |
| SCHEMBL12886188 | 0.75 | ALDH1A1 (0.50) | LMNATHRBKMT2AALDH1A1TSHR | |
| SCHEMBL26342933 | 0.75 | LMNA (0.38) | LMNATHRBKMT2AALDH1A1TSHR | |
| SCHEMBL460115 | 0.75 | LMNA (0.38) | LMNATHRBKMT2AALDH1A1TSHR | |
| SCHEMBL347950 | 0.74 | — | — | |
| SCHEMBL346110 | 0.73 | FFAR3 (0.48) | LMNATHRBKMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104755482-A | Functionalized 9-bromo-camptothecin derivatives | NERVIANO MEDICAL SCIENCES SRL | 2015-07-01 | — | — | CN | claimed |
| CN-104755482-B | functionalized 9-bromo-camptothecin derivatives | 内尔维阿诺医学科学有限公司 | 2017-04-26 | — | — | CN | disclosed |
| CN-104755482-A | Functionalized 9-bromo-camptothecin derivatives | NERVIANO MEDICAL SCIENCES SRL | 2015-07-01 | — | — | CN | disclosed |
| CN-102417480-A | Spirocyclic nitriles as protease inhibitors | SANOFI AVENTIS | 2012-04-18 | — | — | CN | disclosed |
| EP-1414792-A1 | FLUORO LINKERS AND THEIR USE AS LINKERS FOR ENZYME-ACTIVATED DRUG CONJUGATES | Pharmacia Italia S.p.A. (IT) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003014069-A1 | FLUORO LINKERS AND THEIR USE AS LINKERS FOR ENZYME-ACTIVATED DRUG CONJUGATES | PHARMACIA ITALIA SPA (IT) | 2003-02-20 | — | — | WO | disclosed |