Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.60 |
| ▸ | PGR | P06401 | 9/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584678 | 0.99 | MAOB (0.58) | MAOBPGRPDK2PDK4PDE3B | |
| SCHEMBL6583303 | 0.96 | MAOB (0.61) | MAOBPGRPDK2PDK4PDE3B | |
| SCHEMBL6583223 | 0.93 | MAOB (0.61) | MAOBPGRPDK2PDK4PDE3B | |
| SCHEMBL6585088 | 0.89 | MAOB (0.47) | MAOBPGRPDK2PDK4MAOA | |
| SCHEMBL10834864 | 0.87 | MAOB (0.55) | MAOBPGRPDK2PDK4PDE3B | |
| SCHEMBL6584050 | 0.87 | MAOB (0.46) | MAOBPGRPDK2PDK4MAOA | |
| SCHEMBL10834397 | 0.86 | MAOB (0.54) | MAOBPGRPDK2PDK4PDE3B | |
| SCHEMBL6583879 | 0.84 | MAOB (0.48) | MAOBPGRPDK2PDK4MAOA | |
| SCHEMBL10834540 | 0.84 | MAOB (0.52) | MAOBPGRPDK2PDK4PDE3B | |
| SCHEMBL10926800 | 0.83 | MAOB (0.51) | MAOBPGRPDK2PDK4PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |
| US-4629733-A | CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1986-12-16 | — | — | US | disclosed |