SCHEMBL6584915

SCHEMBL6584915

CN1CC[C@@H]1COc1cnc(Cl)c(CNC(=O)CCc2ccccc2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 5/20 0.48
CHRNB4 P30926 4/20 0.48
CHRNB2 P17787 3/20 0.48
CHRNB1 P11230 2/20 0.48
CHRNB3 Q05901 2/20 0.48
JAK2 O60674 1/20 0.48
DAPK3 O43293 1/20 0.45
ROCK2 O75116 1/20 0.45
PRKCG P05129 1/20 0.45
PIM1 P11309 1/20 0.45
RPS6KB1 P23443 1/20 0.45
AKT1 P31749 1/20 0.45
LIMK1 P53667 1/20 0.45
CDK5 Q00535 1/20 0.45
PRKCD Q05655 1/20 0.45
PAK1 Q13153 1/20 0.45
STK3 Q13188 1/20 0.45
ROCK1 Q13464 1/20 0.45
DYRK1A Q13627 1/20 0.45
CDC42BPA Q5VT25 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6582165 0.86 CHRNA3 (0.49) CHRNA3CHRNB4CHRNB2CHRNB1CHRNB3
Hydrochloric Acid SCHEMBL6588512 0.85 CHRNA3 (0.48) CHRNA3CHRNB4CHRNB2CHRNB1CHRNB3
SCHEMBL8150134 0.83 CHRNA3 (0.51) CHRNA3CHRNB4CHRNB2CHRNB1CHRNB3
SCHEMBL8155391 0.83 CHRNA3 (0.54) CHRNA3CHRNB4CHRNB2CHRNB1CHRNB3
SCHEMBL6582895 0.83 CHRNA3 (0.47) CHRNA3CHRNB4CHRNB2CHRNB1CHRNB3
Hydrochloric Acid SCHEMBL6586429 0.82 CHRNA3 (0.50) CHRNA3CHRNB4CHRNB2CHRNB1CHRNB3
SCHEMBL8507104 0.76 ALDH1A1 (0.42) ALDH1A1
SCHEMBL6587453 0.74 CHRNB4 (0.51) CHRNA3CHRNB4CHRNB2CHRNB1CHRNB3
SCHEMBL7825956 0.74 CHRNA3 (0.57) CHRNA3CHRNB4CHRNB2CHRNB1CHRNB3
SCHEMBL7825981 0.74 CHRNA3 (0.57) CHRNA3CHRNB4CHRNB2CHRNB1CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP claimed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US claimed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed
US-5629325-A TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS ABBOTT LABORATORIES (US) 1997-05-13 US disclosed