Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL658734 | 0.85 | TRPV1 (0.60) | TRPV1KDM4EMAPT | |
| SCHEMBL287455 | 0.78 | TRPV1 (0.57) | TRPV1MAPK13MAPK12MAPK11MAPK14 | |
| Hydrochloric Acid SCHEMBL12982494 | 0.77 | TRPV1 (0.56) | TRPV1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL22385170 | 0.76 | TRPV1 (0.64) | TRPV1 | |
| SCHEMBL13194016 | 0.76 | TRPV1 (0.64) | TRPV1 | |
| SCHEMBL6266715 | 0.74 | ALDH1A1 (0.60) | SIGMAR1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL2688130 | 0.74 | TRPV1 (0.72) | TRPV1 | |
| SCHEMBL287373 | 0.73 | TRPV1 (0.56) | TRPV1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9374413 | 0.73 | SIGMAR1 (0.76) | SIGMAR1LMNAMAPTHTR1AHTR7 | |
| SCHEMBL25510561 | 0.71 | TRPV1 (0.47) | TRPV1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046301-A1 | Substituted Cyclic Carboxamide and Urea Derivatives as Ligands of the Vanilloid Receptor | GRUENENTHAL GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046301-A1 | Substituted Cyclic Carboxamide and Urea Derivatives as Ligands of the Vanilloid Receptor | TRPV1, CNR1, CNR2 | TRPV1 1/4885SIGMAR1 24/4885MAPK13 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.