Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23914748 | 0.83 | SMN1; SMN2 (0.69) | ALDH1A1SMN1; SMN2GAAHPGDRAB9A | |
| SCHEMBL25310305 | 0.83 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2TSHRLMNAKDM4E | |
| SCHEMBL6589118 | 0.82 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2GAAHPGDLMNA | |
| SCHEMBL4837939 | 0.80 | MAPT (0.47) | ALDH1A1SMN1; SMN2GAATSHRMAPT | |
| SCHEMBL4117496 | 0.80 | GAA (0.51) | SMN1; SMN2GAATSHRLMNAKDM4E | |
| SCHEMBL6587879 | 0.78 | ALDH1A1 (0.46) | ALDH1A1GAAHPGDNPC1RAB9A | |
| SCHEMBL4131883 | 0.76 | GAA (0.50) | SMN1; SMN2GAATSHRLMNAKDM4E | |
| SCHEMBL4841413 | 0.76 | PARP1 (0.51) | SMN1; SMN2GAATSHRMAPTENPP1 | |
| SCHEMBL6588241 | 0.75 | LMNA (0.51) | ALDH1A1SMN1; SMN2GAAHPGDNPC1 | |
| SCHEMBL25309821 | 0.75 | SMN1; SMN2 (0.70) | ALDH1A1SMN1; SMN2TSHRLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| EP-1371648-A1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.p.A. (IT) | 2003-12-17 | — | — | EP | disclosed |
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |
| EP-1097142-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000005218-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2000-02-03 | — | — | WO | disclosed |