Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411092 | 0.91 | ENPP2 (0.34) | ENPP2 | |
| SCHEMBL6589307 | 0.81 | MAOB (0.38) | — | |
| SCHEMBL6585338 | 0.76 | ENPP2 (0.41) | ENPP2MGLLCA1CA2 | |
| SCHEMBL7412493 | 0.76 | ALDH1A1 (0.36) | — | |
| SCHEMBL3577660 | 0.70 | ENPP2 (0.61) | ENPP2MGLLCA1CA2NLRP3 | |
| SCHEMBL7411096 | 0.69 | ENPP2 (0.34) | ENPP2 | |
| SCHEMBL7998 | 0.67 | ENPP2 (0.63) | ENPP2MGLLCA1CA2NLRP3 | |
| SCHEMBL23364676 | 0.66 | ENPP2 (0.58) | ENPP2MGLLCA1CA2NLRP3 | |
| SCHEMBL8472790 | 0.65 | CYP3A4 (0.41) | — | |
| SCHEMBL29955003 | 0.65 | ENPP2 (0.56) | ENPP2MGLLNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |