Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804664 | 0.85 | PARP1 (0.51) | PARP1PKN1PKN2 | |
| SCHEMBL6589472 | 0.83 | PKN2 (0.39) | PARP1HPSEPKN1PKN2PLA2G2A | |
| SCHEMBL6587689 | 0.82 | PARP1 (0.39) | PARP1HPSECBFBPLA2G2AALOX15 | |
| SCHEMBL6591556 | 0.80 | PARP1 (0.40) | PARP1HPSEPKN1PKN2PLA2G2A | |
| SCHEMBL6586846 | 0.78 | PARP1 (0.46) | PARP1 | |
| SCHEMBL6591532 | 0.75 | PARP1 (0.41) | PARP1HPSEPLA2G2AALOX15PTGS2 | |
| SCHEMBL6589114 | 0.74 | PARP1 (0.57) | PARP1HPSEPKN1PKN2CBFB | |
| SCHEMBL6591503 | 0.73 | PARP1 (0.44) | PARP1HPSEPKN1PKN2PLA2G2A | |
| SCHEMBL6804675 | 0.73 | PARP1 (0.36) | PARP1PKN1PKN2 | |
| SCHEMBL6591536 | 0.72 | PARP1 (0.39) | PARP1HPSECBFBPLA2G2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |