Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804664 | 0.83 | PARP1 (0.51) | PARP1PLK4MAP4K4PRKXROCK1 | |
| SCHEMBL6805937 | 0.82 | PLK4 (0.39) | PARP1PLK4CHEK1AURKADAPK3 | |
| SCHEMBL6807486 | 0.81 | AURKA (0.38) | PARP1KDM4EMAPTPLK4CHEK1 | |
| SCHEMBL6805212 | 0.78 | PARP1 (0.39) | PARP1PLK4CHEK1AURKADAPK3 | |
| SCHEMBL6805469 | 0.76 | NPC1 (0.43) | PARP1SMN1; SMN2 | |
| SCHEMBL6807302 | 0.73 | TRPV1 (0.42) | PARP1MAPTTP53SMN1; SMN2 | |
| SCHEMBL6586253 | 0.73 | PARP1 (0.38) | PARP1PKN1PKN2 | |
| SCHEMBL6806365 | 0.73 | PARP1 (0.54) | PARP1PLK4CHEK1AURKADAPK3 | |
| SCHEMBL6807466 | 0.72 | ALDH1A1 (0.42) | PARP1KDM4EMAPTPLK4CHEK1 | |
| SCHEMBL29696369 | 0.68 | NPC1 (0.53) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |