Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.46 |
| ▸ | DHODH | Q02127 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591532 | 0.88 | PARP1 (0.41) | PARP1PARP2 | |
| SCHEMBL6805464 | 0.84 | PARP1 (0.67) | PARP1DHODHCHEK2PARP2 | |
| SCHEMBL6591556 | 0.81 | PARP1 (0.40) | PARP1PARP2 | |
| SCHEMBL6587689 | 0.79 | PARP1 (0.39) | PARP1CHEK2PARP2 | |
| SCHEMBL6589472 | 0.78 | PKN2 (0.39) | PARP1 | |
| SCHEMBL6586253 | 0.78 | PARP1 (0.38) | PARP1 | |
| SCHEMBL6589114 | 0.78 | PARP1 (0.57) | PARP1DHODHCHEK2PARP2 | |
| SCHEMBL6590776 | 0.77 | PARP1 (0.46) | PARP1DHODHCHEK2 | |
| SCHEMBL6587155 | 0.77 | PARP1 (0.44) | PARP1DHODHCHEK2 | |
| SCHEMBL6585207 | 0.77 | PARP1 (0.51) | PARP1DHODHCHEK2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |