Sugi Predict

Sugi Predict / Compounds / SCHEMBL6586273

SCHEMBL6586273

SCHEMBL6586273

C=CC[C@@](C)(C(=O)NO)S(=O)(=O)N1CC=C(c2ccc(-c3ccccc3)c(C)c2)CC1

nearest known ligand 0.65

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 13/20 0.65
▸ MMP3 P08254 13/20 0.65
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ MMP1 P03956 1/20 0.38
▸ MMP9 P14780 1/20 0.38
▸ MMP14 P50281 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6586265 1.00 MMP2 (0.65) MMP2MMP3L3MBTL1MMP1MMP9
SCHEMBL6586269 1.00 MMP2 (0.65) MMP2MMP3L3MBTL1MMP1MMP9
SCHEMBL6585475 0.91 MMP2 (0.61) MMP2MMP3L3MBTL1
SCHEMBL6585480 0.91 MMP2 (0.61) MMP2MMP3L3MBTL1
SCHEMBL6585478 0.91 MMP2 (0.61) MMP2MMP3L3MBTL1
SCHEMBL6583784 0.90 MMP2 (0.60) MMP2MMP3L3MBTL1
SCHEMBL6583790 0.90 MMP2 (0.60) MMP2MMP3L3MBTL1
SCHEMBL6583787 0.90 MMP2 (0.60) MMP2MMP3L3MBTL1
SCHEMBL6586215 0.79 MMP3 (1.00) MMP2MMP3L3MBTL1
SCHEMBL6585881 0.79 MMP2 (0.66) MMP2MMP3L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1036062-B1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS PFIZER LTD (GB) 2004-01-02 — — EP disclosed
US-6495568-B1 TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES WARNER-LAMBERT COMPANY 2002-12-17 — — US disclosed