Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FPR3 | P25089 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6341467 | 0.80 | HRH3 (0.57) | SIGMAR1HRH3PKMGAASMN1; SMN2 | |
| SCHEMBL6338600 | 0.79 | SIGMAR1 (0.58) | SIGMAR1HRH3 | |
| SCHEMBL6338599 | 0.79 | SIGMAR1 (0.58) | SIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL6406743 | 0.76 | SIGMAR1 (0.58) | SIGMAR1HRH3GAASMN1; SMN2FPR3 | |
| SCHEMBL4412835 | 0.76 | CHRM2 (0.54) | SIGMAR1HRH3SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6338738 | 0.75 | SIGMAR1 (0.59) | SIGMAR1HRH3GAASMN1; SMN2FPR3 | |
| SCHEMBL4551826 | 0.75 | MCHR1 (0.53) | SIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL6341471 | 0.72 | SIGMAR1 (0.76) | SIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL6336991 | 0.72 | HRH3 (0.67) | SIGMAR1HRH3GAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6339591 | 0.72 | HRH3 (0.63) | SIGMAR1HRH3PKMGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056733-B1 | HISTAMINE H3 RECEPTOR LIGANDS | BLACK JAMES FOUNDATION (GB) | 2004-01-07 | — | — | EP | disclosed |
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |