Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.42 |
| ▸ | SORD | Q00796 | 8/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6293205 | 0.83 | SORD (0.39) | SORDKDM4E | |
| SCHEMBL6293552 | 0.82 | PRKCQ (0.46) | SORD | |
| SCHEMBL7489299 | 0.81 | SORD (0.53) | SORD | |
| SCHEMBL6294566 | 0.81 | SORD (0.39) | SORDKDM4E | |
| SCHEMBL6294632 | 0.80 | SORD (0.39) | SORDKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL6293410 | 0.79 | SORD (0.38) | SORDKDM4EKMT2A | |
| SCHEMBL6224825 | 0.78 | HRH3 (0.54) | HRH3HRH4SORDKDM4ECYP1A2 | |
| SCHEMBL6293393 | 0.78 | SORD (0.42) | SORD | |
| SCHEMBL3640716 | 0.77 | HRH3 (0.52) | HRH3HRH4SORDKDM4ECYP1A2 | |
| SCHEMBL6297889 | 0.77 | SORD (0.41) | SORD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041068-B1 | Compounds for treating and preventing diabetic complications | PFIZER PROD INC (US) | 2004-04-14 | — | — | EP | disclosed |
| US-6294538-B1 | ANTIDIABETIC AGENTS AND DIABETIC NEUROPATHY, TREATMENT WITH OXIDOREDUCTASE ENZYMES | PFIZER INC. | 2001-09-25 | — | — | US | disclosed |
| EP-1041068-A1 | Compounds for treating and preventing diabetic complications | Pfizer Products Inc. (US) | 2000-10-04 | — | — | EP | disclosed |