SCHEMBL6586720

SCHEMBL6586720

Cc1nc(O)cc(-c2ccc(Cl)cc2Cl)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.54
HSP90AB1 P08238 2/20 0.54
MAPT P10636 4/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
HSD11B1 P28845 2/20 0.45
LMNA P02545 1/20 0.43
ALPL P05186 4/20 0.42
KDM4E B2RXH2 2/20 0.41
DHODH Q02127 1/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
CRHR1 P34998 1/20 0.40
PFKFB3 Q16875 1/20 0.39
PIK3CA P42336 1/20 0.39
PIK3CB P42338 1/20 0.39
PIK3CG P48736 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6589616 0.83 HSP90AA1 (0.65) HSP90AA1HSP90AB1MAPTNPC1RAB9A
SCHEMBL27030857 0.82 CXCL12 (0.38) HSP90AA1HSP90AB1MAPTMEN1KMT2A
SCHEMBL6588868 0.81 HSP90AA1 (0.47) HSP90AA1HSP90AB1MAPTNPC1RAB9A
SCHEMBL8481461 0.75 NUDT1 (0.48) HSP90AA1LMNAPFKFB3
SCHEMBL3605062 0.72 HSP90AA1 (0.46) HSP90AA1HSP90AB1MAPTNPC1RAB9A
SCHEMBL8698255 0.71 MAPT (0.53) HSP90AA1HSP90AB1MAPTNPC1RAB9A
SCHEMBL2615267 0.69 HSP90AA1 (0.57) HSP90AA1HSP90AB1MAPTNPC1RAB9A
SCHEMBL7591843 0.69 LMNA (0.53) HSP90AA1HSP90AB1MAPTNPC1RAB9A
SCHEMBL3609043 0.68 HSP90AA1 (0.48) HSP90AA1HSP90AB1MAPTNPC1RAB9A
SCHEMBL30075906 0.68 HSP90AA1 (0.51) HSP90AA1HSP90AB1MAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0781766-B1 HETEROCYCLIC DERIVATIVE AND MEDICINE NIPPON SHINYAKU CO LTD (JP) 2004-03-31 EP disclosed
US-6191149-B1 DRUG FOR CEREBROVASCULAR DISEASE NIPPON SHINYAKU, CO., LTD. (JP) 2001-02-20 US disclosed
US-5945426-A PREVENT NEURONAL DEATH NIPPON SHINYAKU CO., LTD. (JP) 1999-08-31 US disclosed
EP-0781766-A1 HETEROCYCLIC DERIVATIVE AND MEDICINE NIPPON SHINYAKU COMPANY, LIMITED (JP) 1997-07-02 EP disclosed