Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 18/20 | 0.53 |
| ▸ | MMP3 | P08254 | 18/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586861 | 0.88 | MMP2 (0.52) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6439725 | 0.85 | MMP2 (0.62) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6582915 | 0.85 | MMP2 (0.72) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6585861 | 0.84 | MMP3 (0.60) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6590027 | 0.83 | MMP2 (0.61) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6586866 | 0.80 | MMP2 (0.54) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6584020 | 0.78 | MMP2 (0.72) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6590361 | 0.78 | MMP3 (0.60) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6584515 | 0.76 | MMP2 (0.59) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6586191 | 0.76 | MMP2 (0.76) | MMP2MMP3MMP1MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |