Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662147 | 0.81 | ESR2 (0.39) | UCHL1LMNANPSR1GPR119ESR2 | |
| SCHEMBL6583488 | 0.78 | UCHL1 (0.40) | UCHL1LMNANPSR1USP30GPR119 | |
| SCHEMBL6585089 | 0.74 | LMNA (0.44) | UCHL1LMNANPSR1USP30CYP1A2 | |
| SCHEMBL31233813 | 0.71 | NOTUM (0.42) | UCHL1USP30GPR119POLBMEN1 | |
| SCHEMBL26117919 | 0.71 | NOTUM (0.42) | UCHL1USP30GPR119POLBMEN1 | |
| SCHEMBL6584763 | 0.70 | LMNA (0.38) | UCHL1LMNANPSR1USP30GPR119 | |
| SCHEMBL3902271 | 0.70 | CNR2 (0.52) | UCHL1GPR119CYP3A4CYP2C19ESR2 | |
| SCHEMBL6585116 | 0.68 | LMNA (0.35) | UCHL1LMNANPSR1GPR119MEN1 | |
| SCHEMBL2895132 | 0.68 | CHRM4 (0.56) | UCHL1GPR119MAPTESR2CHRM4 | |
| SCHEMBL6584772 | 0.68 | LMNA (0.35) | UCHL1LMNANPSR1USP30GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944621-B1 | 2-IMIDAZOLINYLAMINOINDOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2004-09-01 | — | — | EP | disclosed |
| US-6395764-B1 | NOSAL DECONGESTION, RESPIRATORY SYSTEM DISORDERS | THE PROCTER & GAMBLE COMPANY | 2002-05-28 | — | — | US | disclosed |
| US-6162818-A | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 2000-12-19 | — | — | US | disclosed |