SCHEMBL6586979

SCHEMBL6586979

CCCCCCC#Cc1cncc(OC[C@H]2CCCN2C(=O)OC(C)(C)C)c1

nearest known ligand 0.63

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 12/20 0.63
CHRNB2 P17787 11/20 0.63
CHRNA2 Q15822 2/20 0.50
CHRNB4 P30926 5/20 0.45
CHRNB1 P11230 2/20 0.45
CHRNB3 Q05901 2/20 0.45
CHRNA4 P43681 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6587133 1.00 CHRNA3 (0.63) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1
SCHEMBL14941891 0.97 CHRNB2 (0.68) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1
SCHEMBL14941878 0.97 CHRNB2 (0.68) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1
SCHEMBL6584907 0.95 CHRNA3 (0.58) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1
SCHEMBL2496710 0.92 CHRNA3 (0.70) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1
SCHEMBL2494863 0.92 CHRNA3 (0.69) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1
SCHEMBL14941778 0.91 CHRNB2 (0.62) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1
SCHEMBL6584809 0.91 CHRNB2 (0.62) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1
SCHEMBL2494032 0.87 CHRNA3 (0.64) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1
SCHEMBL2497766 0.86 CHRNB2 (0.63) CHRNA3CHRNB2CHRNA2CHRNB4CHRNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP disclosed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed