Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2271167 | 0.85 | KDM4E (0.64) | HDAC1HDAC2HDAC3KDM4EMAPK1 | |
| SCHEMBL12369428 | 0.81 | HDAC2 (0.72) | HDAC1HDAC2KDM4EMAPK1HSD17B10 | |
| SCHEMBL12369429 | 0.79 | KDM4E (0.60) | HDAC1HDAC2HDAC3KDM4EMAPK1 | |
| SCHEMBL2273074 | 0.78 | HDAC1 (0.52) | HDAC1HDAC2HDAC3KDM4EMAPK1 | |
| SCHEMBL14428246 | 0.78 | HDAC1 (0.57) | HDAC1HDAC2HDAC3KDM4EMAPK1 | |
| SCHEMBL2273085 | 0.78 | ACLY (0.60) | HDAC1HDAC2HDAC3MAPK1LMNA | |
| SCHEMBL12369435 | 0.78 | HDAC2 (0.67) | HDAC1HDAC2HDAC3KDM4EMAPK1 | |
| SCHEMBL1318407 | 0.77 | HSD17B2 (0.54) | HDAC1HDAC2HDAC3KDM4ESMN1; SMN2 | |
| SCHEMBL2274003 | 0.77 | HDAC2 (0.66) | HDAC2KDM4EMAPK1HSD17B10LMNA | |
| SCHEMBL27696833 | 0.77 | HDAC1 (0.46) | HDAC1HDAC2HDAC3KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472216-A2 | NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | Axys Pharmaceuticals (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003066579-A2 | NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS (US) | 2003-08-14 | — | — | WO | disclosed |