Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | PTDSS1 | P48651 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591727 | 0.90 | MAP2K7 (0.38) | PDGFRBAURKBMAP2K7KITPDGFRA | |
| SCHEMBL6587748 | 0.86 | GAA (0.36) | MAP2K7KDRTP53AURKAMAPT | |
| SCHEMBL6589079 | 0.85 | MAP2K4 (0.35) | MAP2K7KDRPDE5APDE1APDE1B | |
| SCHEMBL6585177 | 0.84 | MAP2K4 (0.35) | AURKBMAP2K7KITPDE5APDE1A | |
| SCHEMBL6592076 | 0.84 | PDE5A (0.33) | MAP2K7P2RX7PTDSS1PDE5APDE1A | |
| SCHEMBL6591549 | 0.83 | GAA (0.37) | AURKBAURKAUSP2MAPTHSP90AA1 | |
| SCHEMBL6586649 | 0.82 | KIF11 (0.38) | CDK8ROCK1NTRK2AURKBCLK4 | |
| SCHEMBL6585445 | 0.82 | MAP2K4 (0.35) | CDK8ATMMAP2K7KITPDGFRA | |
| SCHEMBL6588565 | 0.81 | PDE5A (0.34) | MAP2K7PDE5APDE1APDE1BPDE3B | |
| SCHEMBL2947674 | 0.80 | L3MBTL1 (0.47) | MEN1KMT2ANPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1244632-A1 | PYRAZOLE DERIVATIVES WHICH MODULATE HUMAN SEROTONIN RECEPTORS | Arena Pharmaceuticals, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001029008-A1 | PYRAZOLE DERIVATIVES WHICH MODULATE HUMAN SEROTONIN RECEPTORS | ARENA PHARMACEUTICALS, INC. (US) | 2001-04-26 | — | — | WO | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |