Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL509054 | 1.00 | PDE3B (0.42) | PDE3BPDE3AGPR84POLBLMNA | |
| SCHEMBL6586708 | 1.00 | PDE3B (0.42) | PDE3BPDE3AGPR84POLBLMNA | |
| Hydrochloric Acid SCHEMBL6293152 | 0.98 | PDE3B (0.41) | PDE3BPDE3AGPR84POLBLMNA | |
| Hydrochloric Acid SCHEMBL6293153 | 0.98 | PDE3B (0.41) | PDE3BPDE3AGPR84POLBLMNA | |
| SCHEMBL22275400 | 0.80 | PDE3B (0.39) | PDE3BPDE3AGPR84POLBLMNA | |
| SCHEMBL6293377 | 0.75 | PDE3B (0.39) | PDE3BPDE3AGPR84POLBLMNA | |
| SCHEMBL6293376 | 0.75 | PDE3B (0.39) | PDE3BPDE3AGPR84POLBLMNA | |
| SCHEMBL22487895 | 0.73 | GPR84 (0.44) | PDE3BPDE3AGPR84POLBLMNA | |
| SCHEMBL4552845 | 0.72 | POLB (0.38) | PDE3BPDE3AGPR84POLBLMNA | |
| SCHEMBL6297952 | 0.70 | GPR84 (0.39) | PDE3BPDE3AGPR84POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041068-B1 | Compounds for treating and preventing diabetic complications | PFIZER PROD INC (US) | 2004-04-14 | — | — | EP | disclosed |
| US-6294538-B1 | ANTIDIABETIC AGENTS AND DIABETIC NEUROPATHY, TREATMENT WITH OXIDOREDUCTASE ENZYMES | PFIZER INC. | 2001-09-25 | — | — | US | disclosed |
| EP-1041068-A1 | Compounds for treating and preventing diabetic complications | Pfizer Products Inc. (US) | 2000-10-04 | — | — | EP | disclosed |