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SCHEMBL6587292

SCHEMBL6587292

CCOc1cccc(-c2ccc(C3CCN(S(=O)(=O)C(C)(CO)CNC(=O)c4ccccc4O)CC3)cc2C)n1

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 7/20 0.58
▸ MMP3 P08254 7/20 0.58
▸ MMP1 P03956 2/20 0.58
▸ MMP9 P14780 2/20 0.58
▸ MMP14 P50281 2/20 0.58
▸ GUCY1A1 Q02108 9/20 0.34
▸ GUCY1B1 Q02153 9/20 0.34
▸ FFAR4 Q5NUL3 2/20 0.33
▸ USP5 P45974 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6965292 0.94 MMP2 (0.67) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6972711 0.93 MMP2 (0.60) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6586529 0.86 MMP2 (0.65) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6590134 0.82 MMP2 (0.66) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6972911 0.82 MMP2 (0.42) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6588282 0.81 MMP2 (0.67) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6586527 0.80 MMP2 (0.71) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6586414 0.80 MMP2 (0.54) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6588355 0.80 MMP2 (0.70) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6584994 0.79 MMP2 (0.85) MMP2MMP3MMP1MMP9MMP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1036062-B1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS PFIZER LTD (GB) 2004-01-02 — — EP claimed