Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 3/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2401141 | 0.93 | MEN1 (0.46) | AGERMTNR1AHSD11B1HDAC3HDAC8 | |
| SCHEMBL3117999 | 0.90 | AGER (0.48) | AGERMTNR1AHSD11B1HDAC3HDAC8 | |
| SCHEMBL18172734 | 0.89 | HDAC8 (0.45) | HSD11B1HDAC3HDAC8HDAC6GPR119 | |
| SCHEMBL18173247 | 0.88 | HSD11B1 (0.43) | HSD11B1HDAC3HDAC8HDAC6GPR119 | |
| SCHEMBL21088550 | 0.87 | HTR2A (0.44) | AGERMTNR1AHSD11B1HDAC3HDAC8 | |
| SCHEMBL3143765 | 0.86 | HSD11B1 (0.43) | AGERMTNR1AHSD11B1HDAC3HDAC8 | |
| SCHEMBL18617685 | 0.86 | HDAC6 (0.49) | HSD11B1HDAC3HDAC8HDAC6GPR119 | |
| SCHEMBL2586550 | 0.86 | HSD11B1 (0.43) | AGERMTNR1AHSD11B1HDAC3HDAC8 | |
| SCHEMBL27884072 | 0.86 | AGER (0.54) | AGERMTNR1AHSD11B1HDAC3HDAC1 | |
| SCHEMBL24619470 | 0.83 | HDAC8 (0.48) | AGERMTNR1AHSD11B1HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169338-B1 | LOW-MOLECULAR INHIBITORS OF COMPLEMENT PROTEASES | ABBOTT GMBH & CO KG (DE) | 2004-11-03 | — | — | EP | disclosed |
| US-6683055-B1 | GUANIDINE OR AMIDINE TERMINED PEPTIDES | BASF AKTIENGESELLSCHAFT (DE) | 2004-01-27 | — | — | US | disclosed |
| CN-1351609-A | Low molecular weight complement protease inhibitors | BASF AG (DE) | 2002-05-29 | — | — | CN | disclosed |