Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 12/20 | 0.41 |
| ▸ | MGAM | O43451 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | SI | P14410 | 5/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807298 | 0.84 | PARP1 (0.60) | PARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6586096 | 0.83 | PARP1 (0.53) | HPSEPARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6587289 | 0.82 | PARP1 (0.49) | HPSEPARP1MGAMGAASI | |
| SCHEMBL6591184 | 0.82 | AURKB (0.44) | HPSEPARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6588713 | 0.81 | HPSE (0.43) | HPSEPARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6588648 | 0.80 | PARP1 (0.40) | HPSEPARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6587303 | 0.76 | EPHX2 (0.52) | HPSEPARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6586851 | 0.76 | PIM1 (0.48) | HPSEPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL6589916 | 0.76 | TUBB4A (0.44) | HPSEPARP1TP53 | |
| SCHEMBL6578530 | 0.75 | PARP1 (0.67) | HPSEPARP1KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |