Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 6/20 | 0.32 |
| ▸ | GRM5 | P41594 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587932 | 0.88 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DSRC | |
| SCHEMBL6586115 | 0.81 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6584106 | 0.73 | ALDH1A1 (0.39) | PDE4APDE4BPDE4CPDE4DSRC | |
| SCHEMBL7983133 | 0.73 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DCYP17A1 | |
| SCHEMBL6585375 | 0.72 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587107 | 0.71 | PDE4D (0.71) | PDE4APDE4BPDE4CPDE4DGRM5 | |
| SCHEMBL26259628 | 0.66 | KCNH2 (0.51) | GRM5KCNH2 | |
| SCHEMBL7446753 | 0.62 | PDE4B (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13907339 | 0.62 | HDAC8 (0.50) | GRM5CHRM2SIGMAR1 | |
| SCHEMBL6586114 | 0.61 | PDE4D (0.51) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |
| EP-1097142-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000005218-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2000-02-03 | — | — | WO | disclosed |