Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 6/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6588521 | 0.99 | PLK1 (0.39) | PLK1PIM1CAMK2DPIK3R1PIK3CA | |
| Trifluoroacetic Acid SCHEMBL6585732 | 0.94 | PLK1 (0.35) | PLK1PIM1CAMK2DPIK3R1PIK3CA | |
| SCHEMBL6588981 | 0.93 | CAMK2D (0.42) | PLK1PIM1CAMK2DGSK3BAURKA | |
| Hydrochloric Acid SCHEMBL6588778 | 0.92 | CAMK2D (0.42) | PLK1PIM1CAMK2DGSK3BAURKA | |
| SCHEMBL6586537 | 0.90 | PIM1 (0.40) | PLK1PIM1CAMK2DGSK3BHTR6 | |
| SCHEMBL6589065 | 0.89 | CAMK2D (0.40) | PLK1PIM1CAMK2DGSK3BHTR6 | |
| SCHEMBL6590083 | 0.89 | PIM1 (0.39) | PLK1PIM1CAMK2DGSK3BHTR6 | |
| Trifluoroacetic Acid SCHEMBL6589143 | 0.89 | PIM1 (0.33) | PLK1PIM1CAMK2DPIK3R1PIK3CA | |
| Hydrochloric Acid SCHEMBL6589219 | 0.88 | CAMK2D (0.39) | PLK1PIM1CAMK2DGSK3BHTR6 | |
| Hydrochloric Acid SCHEMBL6598884 | 0.88 | CAMK2D (0.42) | PLK1PIM1CAMK2DGSK3BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |