Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 7/20 | 0.39 |
| ▸ | QPCT | Q16769 | 4/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6589219 | 0.99 | CAMK2D (0.39) | CAMK2DPIM1PLK1GSK3BQPCT | |
| SCHEMBL6588981 | 0.96 | CAMK2D (0.42) | CAMK2DPIM1PLK1GSK3BHTR6 | |
| Hydrochloric Acid SCHEMBL6588778 | 0.95 | CAMK2D (0.42) | CAMK2DPIM1PLK1GSK3BHTR6 | |
| SCHEMBL6586537 | 0.94 | PIM1 (0.40) | CAMK2DPIM1PLK1GSK3BHTR6 | |
| SCHEMBL6590083 | 0.93 | PIM1 (0.39) | CAMK2DPIM1PLK1GSK3BHTR6 | |
| Hydrochloric Acid SCHEMBL6598884 | 0.92 | CAMK2D (0.42) | CAMK2DPIM1PLK1GSK3BQPCT | |
| SCHEMBL6588432 | 0.91 | GSK3B (0.42) | CAMK2DPIM1PLK1GSK3BHTR6 | |
| SCHEMBL6588231 | 0.91 | CAMK2D (0.51) | CAMK2DPIM1PLK1GSK3BPDK1 | |
| Hydrochloric Acid SCHEMBL6592479 | 0.90 | PLK1 (0.42) | CAMK2DPIM1PLK1GSK3BQPCT | |
| SCHEMBL6589392 | 0.90 | GSK3B (0.41) | CAMK2DPIM1PLK1GSK3BQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |