Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 3/20 | 0.57 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6588050 | 1.00 | HTR4 (0.57) | HTR4ACHECYP3A4 | |
| Fumaric Acid SCHEMBL6588341 | 0.90 | HTR4 (0.70) | HTR4ACHECYP3A4 | |
| Fumaric Acid SCHEMBL6588349 | 0.90 | HTR4 (0.70) | HTR4ACHECYP3A4 | |
| Fumaric Acid SCHEMBL6590457 | 0.89 | HTR4 (0.60) | HTR4ACHECYP3A4 | |
| Fumaric Acid SCHEMBL6590444 | 0.89 | HTR4 (0.60) | HTR4ACHECYP3A4 | |
| SCHEMBL6587254 | 0.85 | HTR4 (0.62) | HTR4ACHE | |
| SCHEMBL6586647 | 0.85 | HTR4 (0.76) | HTR4ACHECYP3A4 | |
| Fumaric Acid SCHEMBL6590853 | 0.80 | HTR4 (0.59) | HTR4ACHECYP3A4 | |
| Fumaric Acid SCHEMBL6590846 | 0.80 | HTR4 (0.59) | HTR4ACHECYP3A4 | |
| Fumaric Acid SCHEMBL6586291 | 0.80 | HTR4 (0.60) | HTR4ACHECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076055-B1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | DAINIPPON PHARMACEUTICAL CO (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6294555-B1 | SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-1076055-A1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2001-02-14 | — | — | EP | disclosed |